Master Discussion
The College of Science for Women / University of Baghdad examined the dissertation entitled (Synthesis of Phenolic Nanoparticles from Bacopa monnieri and Evaluation of Their Antibiofilm of Serratia marcescens) of the student (Maysam Ihsan Ali Al-Hassany), in Partial Fulfilment of the Requirements for the Degree of Doctor in Biology/Botany.
The dissertation was conducted to synthesize phenolic and flavonoid nanoparticles from Bacopa monnieri ultrasonic method and to evaluate their effects on biofilm formation, and the expression of genes (fimA and smaI) in Serratia marcescens.
This research focuses on developing natural plant-based nanomaterials as alternative antimicrobial agents. Phenolic and flavonoid compounds were extracted from Bacopa monnieri, followed by their nano-formulation to enhance bioactivity. The antibiofilm effects were assessed against Serratia marcescens. The findings revealed that nano-phenol and nano-flavonoid displayed superior efficacy compared to phenolic extract and flavonoid extract.
The study concluded that phenolic and flavonoid nanoparticles from Bacopa monnieri, synthesized through nanotechnology, represent a novel and promising approach for combating biofilm-related infections caused by bacteria such as Serratia marcescens. Molecular analysis confirmed that nanoparticle treatment significantly reduced the expression genes fimA and smaI. These findings highlight the potential of plant-derived nanoparticles as eco-friendly and effective alternatives to conventional antimicrobials.
Excellent.
