Master’s Discussion
The College of Science for Women at the University of Baghdad held a Master’s thesis defense titled) Studying the Relationship between Heme Oxygenase -1, Dipeptidyl Peptidase-4, and Other Biochemical Parameters with and without Obese Patients (by the student: Mays Mohammed Abdullah
The objective of this study was to examine the relationship between HO-1 and DPP-4 as predictive factors for developing diabetes or other diseases due to oxidative stress in the study samples represented by obese people with T2DM and those without it. This goal was achieved according to the following steps:
- Estimation of HO-1 and DPP-4 levels in patients and healthy individuals.
- Measurement of insulin and HOMA-IR.
- Determination of the ROC curve to establish normal cutoff values for HO-1 and DPP-4 in patients.
The study was carried out at the University of Baghdad’s College of Science for Women’s Department of Chemistry, the samples were collected from Al-Kindy Teaching Hospital. It comprised 150 samples separated into three groups based on Body Mass Index (BMI), subdivided into two gender-based subgroups (males and females) of individuals age 30 to 65 years. The first group consisted of healthy individuals (control group), consisting of 50 individuals without obesity. The second group consisted of 50 obese individuals with a BMI of 30 kg/m2 or more and diabetic individuals. The third group consisted of 50 obese individuals without diabetes and whose BMI was 30 or more.
Main Recommendations of the Thesis:
- Study HO-1 levels in complications of T2DM patients who treated with insulin injections.
- Study the difference between DPP-4 enzyme levels in normal weight patients with and without T2DM.
- Study of HO-1 and DPP-4 levels in patients with CVD and T2DM.
