The objectives of this study are summarized as follows:

The thesis aimed to investigate the relationship between these newly discovered adipokines and insulin resistance in women diagnosed with Polycystic Ovary Syndrome (PCOS).

The study included the measurement of the concentrations of these adipokines (Asprosin and Subfatin), insulin resistance indices, and sex hormones in Iraqi women diagnosed with PCOS. A total of 120 women were enrolled in the study and divided into three groups: two patient groups, including a normal-weight group and an obese group, while the third group served as the control group. Each group consisted of 40 women. Samples were collected in Baghdad.

1. The results demonstrated a significant increase in Asprosin levels among patients, particularly those with obesity and insulin resistance, suggesting its association with the metabolic alterations accompanying the syndrome.
   The findings also revealed elevated Subfatin levels in women with PCOS who suffered from obesity and insulin resistance, supporting the hypothesis that this adipokine may play a role in the metabolic and inflammatory responses associated with the disorder.
   These findings indicate that Asprosin and Subfatin may serve as promising biomarkers for improving the understanding of the pathophysiological mechanisms underlying PCOS and for assessing the severity of its associated metabolic disturbances.
   The study recommends conducting further clinical and molecular investigations to clarify the precise role of Asprosin and Subfatin in the development of PCOS and to explore their potential applications in early diagnosis, disease monitoring, and future therapeutic strategies.

The final grade: Excellent