The master’s thesis, (Investigating the role of prolyl-endopeptidase in Gluten Sensitivity Patients as a Risk Factor for type1 Diabetes) was the topic of discussion at the College of Science for Women at the University of Baghdad.Student: Fatma Faak Mahmood Jarad
The thesis’s goal is to involves established that celiac disease may contribute to the development of type 1 diabetes. Parameters such as (PREP, tTg-IgA), (HbA1c, FBS) can be used to detect celiac disease and type1 diabetes respectively.
The study was done at the University of Baghdad’s College of Science for Women’s Chemistry Department and at the Children’s Teaching Hospital, Medical City, and Al-Kindi Hospital in Baghdad/Iraq, prolyl-endopeptidase and Anti-tTgA were assessed in the serum of patients using enzyme-linked immunosorbent assay (ELISA) kits. Additionally, HbA1c, FBS, GOT, GPT, and CBC were measured in patient serum through Auto-spectrophotometric analysis. Based on the available data, the results indicated significantly higher levels of PREP, Anti-tTgA, FBS, and HbA1c in untreated gluten patients. The ROC test demonstrated a correlation between HbA1c, FBS, PREP, and Anti-tTgA in diagnosing celiac disease. Further tests revealed that gluten-sensitive patients had elevated levels of other parameters, including CBC, GPT, and GOT, compared to healthy individuals.
The letter makes the following key recommendations:
1- Incorporating PREP and Anti-tTgA in routine tests to aid in the prognosis of CeD.
2- Exploring the effectiveness of using PREP, Anti-tTgA, and HbA1c to differentiate between CeD and T1DM.
3- Investigating the correlation between PREP and HbA1c in gluten-sensitive patients with T1DM.
