College of Science for Women / University of Baghdad examined the thesis (Assessments of Interleukin 35 and Mannose Receptor during chronic Toxoplasma gondii infection) of the student Abeer Hassan Hawi.
The thesis aims to investigate the serum levels of IL-35 and Mannose Receptor in a group of Iraqi women with Toxoplasma gondii.
The thesis includes total of sixty Iraqi female patients with toxoplasmosis (40 pregnant in the first trimester and 20 non-pregnant) were enrolled in the study. A control sample of 50 healthy individuals (25 pregnant in the first trimester and 25 non-pregnant) were included and matched patients for age (15–29 years). After diagnosis by the consultant physician, the subjects were laboratory evaluated for the following serological evidence: C-reactive protein (CRP), HCG pregnancy rapid test, TORCH lgM and lgG rapid test, and CHORUS Toxoplasma IgG avidity test. An enzyme-linked immunosorbent assay (ELISA) was then performed to measure the serum MR and IL-35 levels.
The most important recommendations which the study has come up:
- Study the immune mechanisms underlying the interaction of parasite antigens with CLRs.
- Study the role of other types of CLRs and novel cytokines in toxoplasmosis and different parasitic diseases.
- Correlate the serum levels of MR and IL-35 with their single nucleotide polymorphisms (SNPs) and also study the gene expression.
- Study the virulence factor of gondii with mediators of immune regulation.
The student obtained a very good grade.
