{"id":6237,"date":"2025-01-15T12:40:00","date_gmt":"2025-01-15T09:40:00","guid":{"rendered":"https:\/\/en.csw.uobaghdad.edu.iq\/?p=6237"},"modified":"2025-01-15T12:41:30","modified_gmt":"2025-01-15T09:41:30","slug":"in-a-dissertation-in-the-college-of-science-for-women-investigating-the-role-of-prolyl-endopeptidase-in-gluten-sensitivity-patients-as-a-risk-factor-for-type1-diabetes","status":"publish","type":"post","link":"https:\/\/en.csw.uobaghdad.edu.iq\/?p=6237","title":{"rendered":"In a dissertation in the College of Science for Women, Investigating the role of prolyl-endopeptidase in Gluten Sensitivity Patients as a Risk Factor for type1 Diabetes"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text css=””]The master’s thesis, (Investigating the role of prolyl-endopeptidase in Gluten Sensitivity Patients as a Risk Factor for type1 Diabetes) was the topic of discussion at the College of Science for Women at the University of Baghdad.Student: Fatma Faak Mahmood Jarad<\/p>\n

The thesis’s goal is to involves established that celiac disease may contribute to the development of type 1 diabetes. Parameters such as (PREP, tTg-IgA), (HbA1c, FBS) can be used to detect celiac disease and type1 diabetes respectively.<\/p>\n

The study was done at the University of Baghdad’s College of Science for Women’s Chemistry Department and at the Children’s Teaching Hospital, Medical City, and Al-Kindi Hospital in Baghdad\/Iraq, prolyl-endopeptidase and Anti-tTgA were assessed in the serum of patients using enzyme-linked immunosorbent assay (ELISA) kits. Additionally, HbA1c, FBS, GOT, GPT, and CBC were measured in patient serum through Auto-spectrophotometric analysis. Based on the available data, the results indicated significantly higher levels of PREP, Anti-tTgA, FBS, and HbA1c in untreated gluten patients. The ROC test demonstrated a correlation between HbA1c, FBS, PREP, and Anti-tTgA in diagnosing celiac disease. Further tests revealed that gluten-sensitive patients had elevated levels of other parameters, including CBC, GPT, and GOT, compared to healthy individuals.<\/p>\n

The letter makes the following key recommendations:<\/p>\n

1- Incorporating PREP and Anti-tTgA in routine tests to aid in the prognosis of CeD.<\/p>\n

2- Exploring the effectiveness of using PREP, Anti-tTgA, and HbA1c to differentiate between CeD and T1DM.<\/p>\n

3- Investigating the correlation between PREP and HbA1c in gluten-sensitive patients with T1DM.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]

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