{"id":13811,"date":"2026-08-13T10:54:37","date_gmt":"2026-08-13T07:54:37","guid":{"rendered":"https:\/\/en.csw.uobaghdad.edu.iq\/?p=13811"},"modified":"2026-08-13T11:00:03","modified_gmt":"2026-08-13T08:00:03","slug":"evaluation-of-serum-levels-of-soluble-receptor-for-advanced-glycation-end-products-srage-and-neurokinin-b-as-early-biomarkers-for-predicting-the-risk-of-type-2-diabetes-mellitus-in-obese-individuals","status":"publish","type":"post","link":"https:\/\/en.csw.uobaghdad.edu.iq\/?p=13811","title":{"rendered":"Evaluation of Serum Levels of Soluble Receptor for Advanced Glycation End Products (sRAGE) and Neurokinin B as Early Biomarkers for Predicting the Risk of Type 2 Diabetes Mellitus in Obese Individuals without Diabetes."},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row full_width=&#8221;stretch_row&#8221; rtl_reverse=&#8221;yes&#8221; css=&#8221;.vc_custom_1726859899671{margin-top: -150px !important;padding-top: 150px !important;padding-bottom: 60px !important;background-color: #f5f5f5 !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;]<div class=\"cz_gap clr \" style=\"height: 50px\"><\/div><div class=\"relative\"><div id=\"cz_97039\" class=\"cz_97039 cz_line tal\"><\/div><\/div><div class=\"clr\"><\/div><div id=\"cz_16940\" class=\"cz_16940 cz_title clr cz_mobile_text_center cz_title_pos_inline tac\"><div class=\"cz_title_content\"><div class=\"cz_wpe_content\"><p style=\"text-align: center;\"><span style=\"color: #102d5c; font-family: Montserrat;\"><span style=\"font-size: 38px;\"><span style=\"color: #102d5c;\"><span style=\"color: #f5c538;\">Master\u2019s<\/span> Discussion<\/span><\/span><\/span><\/p>\n<p style=\"text-align: center;\">The College of Science for women at the University of Baghdad discussed the master&#8217;s thesis entitled (Evaluation of Serum Levels of Soluble Receptor for Advanced Glycation End Products (sRAGE) and Neurokinin B as Early Biomarkers for Predicting the Risk of Type 2 Diabetes Mellitus in Obese Individuals without Diabetes)<\/p>\n<p style=\"text-align: center;\"><strong>By the student: Summer Sabah Qasim <\/strong><strong>.<\/strong><\/p>\n<\/div><\/div><\/div><div class=\"cz_gap clr \" style=\"height: 50px\"><\/div><div id=\"cz_81239\" data-arrows='{\"open\":\"fa fa-angle-down\",\"close\":\"fa fa-angle-up\"}' class=\"cz_81239 cz_acc clr\"><div><div id=\"cz_90017\"><span class=\"cz_acc_child\"><i class=\"cz-acc-i cz-acc-icon fa czico-052-three-2\"><\/i><div>Objectives of the Thesis<\/div><\/span><div class=\"cz_acc_child_content clr\">[vc_column_text css=&#8221;&#8221;]<\/p>\n<ol>\n<li>\u00a0The objectives of this study are summarized as follows:\n<ol>\n<li>To measure and compare serum levels of (sRAGE) as well as neurokinin B (NKB) and among obese individuals, patients with T2DM, as well as healthy controls.<\/li>\n<li>To analyze the correlation between sRAGE and NKB levels with other biochemical parameters such as lipid profile, fasting glucose, QUICKI , McAuly index , TYG index as well as BMI.<\/li>\n<li>To evaluate the potential of sRAGE and NKB as early biomarkers for predicting the risk of developing T2DM in obese individuals.<\/li>\n<li>To determine the normal cutoff values for sRAGE and NKB in patient.<\/li>\n<li>To evaluate the potential of Neurokinin-B as a predictive factor or prognostic biomarker for metabolic dysfunction together with insulin resistance and obesity and Type 2 diabetes mellitus severity in both sexes.<\/li>\n<\/ol>\n<p>Other parameters, such as FBS and lipid profile, were also measured in both the patient and healthy control groups.<\/p>\n<p>Quickness, TYG, McAuley, and HOMA-IR were calculated in both the patient and healthy control groups.<\/li>\n<\/ol>\n<p>[\/vc_column_text]<\/div><\/div><div id=\"cz_16394\"><span class=\"cz_acc_child\"><i class=\"cz-acc-i cz-acc-icon fa czico-052-three-2\"><\/i><div>Content of the Thesis<\/div><\/span><div class=\"cz_acc_child_content clr\">[vc_column_text css=&#8221;&#8221;]The study was conducted at the University of Baghdad, College of Science for Women, Department of Chemistry, and the Specialized Center for Endocrinology and Diabetes in Al-Rusafa, Baghdad, Iraq, from October to December 2025. Insulin, sRAGE, and NKB levels were measured using ELISA with a Human Reader HS device, while FBS and lipid profile were examined using a Cecil CE72000 device. The equation method was adopted to calculate QUICKI, TYG, McAuley, and HOMA-IR.[\/vc_column_text]<\/div><\/div><div id=\"cz_39284\"><span class=\"cz_acc_child\"><i class=\"cz-acc-i cz-acc-icon fa czico-052-three-2\"><\/i><div>Recommendation of the Thesis<\/div><\/span><div class=\"cz_acc_child_content clr\">[vc_column_text css=&#8221;&#8221;]<\/p>\n<ol>\n<li>\u00a0The most important recommendations reached by the thesis are:\n<ul>\n<li>Study investigates sRAGE levels as a potential prognostic tool to predict vascular damage and cardiovascular disease development in T2DM patients because sRAGE functions as an inflammatory inhibitor.<\/li>\n<li>Study how Neurokinin-B (NKB) affects appetite control and energy balance and glucose metabolism among people who have different levels of central fat accumulation (WHR).<\/li>\n<li>Study the compared sRAGE , NKB levels and oxidative stress levels between normal-weight people and obese patients who have cardiovascular disease and who do not in order to discover they have cardiovascular disease as early risk indicators.<\/li>\n<li>The study evaluates how different treatment methods like insulin injections and oral glucose-lowering agents affect sRAGE levels and NKB levels to achieve restorative therapy goals.<\/li>\n<li>Need to study how sRAGE levels relate to insulin sensitivity (QUICKI index) across different metabolic syndrome stages because this information helps to prevent future vascular complications.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p>[\/vc_column_text]<\/div><\/div><div id=\"cz_57175\"><span class=\"cz_acc_child\"><i class=\"cz-acc-i cz-acc-icon far fa-image\"><\/i><div>Picture of the Committee members<\/div><\/span><div class=\"cz_acc_child_content clr\">[vc_column_text css=&#8221;&#8221;]<\/p>\n<div class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" class=\"wpa-warning wpa-image-missing-alt aligncenter size-large wp-image-13813\" src=\"https:\/\/en.csw.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/97\/2026\/08\/photo_2_2026-08-09_09-48-26-450x600.jpg\" alt=\"\" width=\"450\" height=\"600\" data-warning=\"Missing alt text\" srcset=\"https:\/\/en.csw.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/97\/2026\/08\/photo_2_2026-08-09_09-48-26-450x600.jpg 450w, https:\/\/en.csw.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/97\/2026\/08\/photo_2_2026-08-09_09-48-26-225x300.jpg 225w, https:\/\/en.csw.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/97\/2026\/08\/photo_2_2026-08-09_09-48-26-768x1024.jpg 768w, https:\/\/en.csw.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/97\/2026\/08\/photo_2_2026-08-09_09-48-26-600x800.jpg 600w, https:\/\/en.csw.uobaghdad.edu.iq\/wp-content\/uploads\/sites\/97\/2026\/08\/photo_2_2026-08-09_09-48-26.jpg 960w\" sizes=\"auto, (max-width: 450px) 100vw, 450px\" \/><\/div>\n<p>[\/vc_column_text]<\/div><\/div><\/div><\/div>[vc_raw_js]JTNDc2NyaXB0JTNFJTIwdmFyJTIwdHJhbnNfcGFnZSUzRCUyMjUzOTM0JTIwJTIyJTIwJTNDJTJGc2NyaXB0JTNF[\/vc_raw_js][\/vc_column][vc_column width=&#8221;1\/2&#8243;]<div class=\"cz_gap clr \" style=\"height: 50px\"><\/div>[vc_single_image image=&#8221;13812&#8243; img_size=&#8221;700&#215;700&#8243; alignment=&#8221;right&#8221; css=&#8221;&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row full_width=&#8221;stretch_row&#8221; rtl_reverse=&#8221;yes&#8221; css=&#8221;.vc_custom_1726859899671{margin-top: -150px !important;padding-top: 150px !important;padding-bottom: 60px !important;background-color: #f5f5f5 !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_raw_js]JTNDc2NyaXB0JTNFJTIwdmFyJTIwdHJhbnNfcGFnZSUzRCUyMjUzOTM0JTIwJTIyJTIwJTNDJTJGc2NyaXB0JTNF[\/vc_raw_js][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;13812&#8243; img_size=&#8221;700&#215;700&#8243; alignment=&#8221;right&#8221; css=&#8221;&#8221;][\/vc_column][\/vc_row] &#8230; <\/p>\n","protected":false},"author":29,"featured_media":13812,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"categories":[15,12],"tags":[],"class_list":["post-13811","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-masters","category-postgraduate-discussions"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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